Guanfacine ER Tablets

Description

Generic Name: Guanfacine ER
Brand Name: Intuniv
Important Warning
Guanfacine ER is a centrally acting alpha-2A adrenergic receptor agonist used primarily in the management of attention deficit hyperactivity disorder (ADHD) in children and adolescents. This medication is not a stimulant and can be used alone or in combination with stimulant medications. Although it can improve focus, attention, and impulse control, it must be used under close medical supervision.

Guanfacine ER should be swallowed whole and not crushed, chewed, or broken. Abruptly stopping the medication can lead to withdrawal symptoms such as increased blood pressure and heart rate, so any changes in dosage should be directed by a healthcare provider.

Uses for Guanfacine ER Tablets
Attention Deficit Hyperactivity Disorder (ADHD): Guanfacine ER is approved for the treatment of ADHD in children and adolescents aged 6 to 17. It can help improve attention, reduce impulsivity, and enhance executive functioning.
Off-Label Uses: In some cases, guanfacine ER may be used off-label for other conditions as deemed appropriate by a healthcare provider.
Before Using Guanfacine ER
Allergies
Inform your doctor if you have any allergies to guanfacine or any other medications. Also mention allergies to foods, dyes, preservatives, or animal products.

Pediatric and Geriatric Use
Pediatric: Guanfacine ER is approved for children and adolescents (6–17 years old) for ADHD. Doses may vary based on weight and response. Close monitoring is required.
Geriatric: Although not commonly used in elderly patients for ADHD, if prescribed for other conditions, older adults may be more sensitive to blood pressure and heart rate changes.
Pregnancy and Breastfeeding
Pregnancy: There is limited data on the use of guanfacine in pregnant women. Use only if clearly needed and as directed by your doctor.
Breastfeeding: It is unknown if guanfacine passes into breast milk. Discuss the potential risks and benefits with your healthcare provider.
Interactions
Medications
Guanfacine ER may interact with:

Antihypertensive drugs: May cause additive effects on lowering blood pressure.
CNS depressants (e.g., benzodiazepines, alcohol): May increase sedation and drowsiness.
Valproic acid: May increase guanfacine levels. Dosage adjustments may be necessary.
Strong CYP3A4 inhibitors or inducers: Can alter guanfacine plasma concentrations.
Food, Alcohol, and Tobacco
Food: Guanfacine ER can be taken with or without food, but a consistent schedule can help maintain stable blood levels.
Alcohol: Avoid alcohol as it can increase drowsiness and dizziness.
Tobacco: No specific known interactions, but discuss all habits with your doctor.
Proper Use of Guanfacine ER Tablets
Dosing Instructions
Take guanfacine ER exactly as prescribed by your doctor.
Typically taken once daily, usually in the morning or evening, depending on your healthcare provider’s instructions.
Swallow tablets whole; do not crush, chew, or split as this can affect the extended-release properties.
Dosage
Children and Adolescents (6–17 years): The usual starting dose is 1 mg daily, which may be increased weekly in increments of no more than 1 mg. The usual target dose ranges from 1 mg to 4 mg daily, depending on response and tolerability.
Dosage should be individualized based on effectiveness and side effects.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is near the time of your next dose, skip the missed dose and resume your regular schedule. Do not double doses.

Storage
Store at room temperature, away from heat, moisture, and direct light. Keep out of reach of children.

Precautions While Using Guanfacine ER
Blood Pressure and Heart Rate: Guanfacine can cause low blood pressure and a slow heart rate. Regular monitoring is important. Rise slowly from sitting or lying positions to reduce dizziness and the risk of falls.
Sedation: Drowsiness, sedation, and fatigue are common, especially when starting therapy or increasing the dose. Avoid driving or operating machinery until you know how guanfacine affects you.
Gradual Discontinuation: Do not stop taking guanfacine suddenly. Tapering off under the guidance of your doctor can help prevent withdrawal symptoms, such as increased blood pressure.
Side Effects of Guanfacine ER Tablets
Serious Side Effects (Seek Immediate Medical Attention)
Severe dizziness, fainting, or irregular heartbeat.
Signs of an allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing.
Common Side Effects
Drowsiness or sedation.
Dry mouth.
Headache.
Dizziness.
Low blood pressure.
Stomach pain or nausea.
Rare Side Effects
Irritability or mood changes.
Skin reactions.
Emergency Situations and Overdose
Symptoms of overdose may include severe drowsiness, very low blood pressure, and slow heart rate. If an overdose is suspected, seek immediate medical attention.

Contact your healthcare provider for any concerns, side effects, or questions regarding guanfacine ER. Follow your doctor’s instructions carefully for safe and effective use.

Full Prescribing Information.
MedlinePlus Patient Information.