Paroxetine ER Tablets

Description

Generic Name: Paroxetine
Brand Names: Paxil, Paxil CR, Pexeva, Brisdelle

Important Warning
Paroxetine is an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class. Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults during the initial treatment period. Patients of all ages should be closely monitored for worsening depression, unusual changes in behavior, or suicidal ideation. Paroxetine is not approved for use in pediatric patients.

Uses for Paroxetine
Paroxetine is prescribed to treat several mental health conditions, including:

Major Depressive Disorder (MDD)
Generalized Anxiety Disorder (GAD)
Social Anxiety Disorder (SAD)
Panic Disorder
Obsessive-Compulsive Disorder (OCD)
Post-Traumatic Stress Disorder (PTSD)
Premenstrual Dysphoric Disorder (PMDD)
Vasomotor symptoms associated with menopause (hot flashes, night sweats)
Paroxetine works by increasing serotonin levels in the brain, which helps improve mood, reduce anxiety, and regulate behavior.

Before Using Paroxetine
Allergies
Inform your doctor if you are allergic to paroxetine or any other medications. Also, mention any allergies to foods, dyes, preservatives, or animals.

Pediatric Use
Paroxetine is not approved for use in children or adolescents.

Geriatric Use
Older adults may be more sensitive to the side effects of paroxetine, particularly hyponatremia (low sodium levels) and an increased risk of falls.

Pregnancy and Breastfeeding
Pregnancy: Paroxetine is not recommended during pregnancy, especially during the first trimester, due to the risk of birth defects. If you become pregnant while taking paroxetine, inform your doctor immediately.
Breastfeeding: Paroxetine may pass into breast milk. Consult your doctor about the risks and benefits of breastfeeding while taking this medication.
Interactions
Medications
Paroxetine may interact with other medications. Inform your doctor if you are taking:

Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, selegiline)—Do not use paroxetine within 14 days of stopping an MAOI.
Other SSRIs or SNRIs
Triptans (e.g., sumatriptan)
Blood thinners (e.g., warfarin, aspirin)
NSAIDs (e.g., ibuprofen, naproxen)
Certain antipsychotics (e.g., thioridazine, pimozide)
Food, Alcohol, and Tobacco
Avoid alcohol while taking paroxetine, as it can worsen side effects such as drowsiness and dizziness.

Medical Conditions
Inform your doctor if you have any of the following conditions:

Bipolar disorder (may trigger a manic episode)
Seizures or epilepsy
Liver or kidney disease
Bleeding disorders
Glaucoma
Low sodium levels (hyponatremia)
Proper Use of Paroxetine
Take paroxetine exactly as prescribed by your doctor. It is usually taken once daily in the morning, with or without food. If it causes drowsiness, your doctor may recommend taking it in the evening.

Dosage
Dosage varies based on the condition being treated. Typical doses are as follows:

Depression/Anxiety Disorders: 20–50 mg per day (initial dose: 20 mg/day)
Panic Disorder: 10–60 mg per day (initial dose: 10 mg/day)
PMDD: 12.5–25 mg per day
Missed Dose
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose. Do not double the dose to make up for a missed one.

Storage
Store at room temperature, away from moisture, heat, and light. Keep out of reach of children.

Precautions While Using Paroxetine
It may take several weeks to feel the full effects of paroxetine. Do not stop taking it suddenly, as withdrawal symptoms (e.g., dizziness, irritability, and insomnia) may occur. Consult your doctor before discontinuing the medication.
Avoid driving or operating heavy machinery until you know how paroxetine affects you, as it may cause drowsiness or dizziness.
Stay hydrated and inform your doctor if you experience symptoms of low sodium levels, such as confusion, headache, or weakness.
Side Effects of Paroxetine
Serious Side Effects (Seek Immediate Medical Attention)
Suicidal thoughts or behavior
Severe allergic reactions (e.g., rash, swelling of the face or throat, difficulty breathing)
Serotonin syndrome (symptoms include agitation, hallucinations, rapid heartbeat, fever, and loss of coordination)
Severe drowsiness or difficulty breathing (may occur when combined with other CNS depressants)
Common Side Effects
Nausea
Drowsiness
Dizziness
Dry mouth
Sweating
Insomnia
Sexual dysfunction (e.g., decreased libido, difficulty achieving orgasm)
Note: Most side effects are mild and resolve as your body adjusts to the medication.

Emergency Situations and Overdose
In case of overdose, symptoms may include seizures, confusion, extreme drowsiness, or irregular heartbeat. Seek emergency medical attention immediately.

Full Prescribing Information.