Sertraline Tablets

Description

Generic Name: Sertraline
Brand Names: Zoloft
Important Warning
Sertraline is an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class. Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults during the early stages of treatment. Patients of all ages should be closely monitored for changes in behavior or mood, especially when starting sertraline or changing the dose. Sertraline is not approved for use in pediatric patients except for those with obsessive-compulsive disorder (OCD).

Uses for Sertraline Tablets
Sertraline is prescribed to treat various mental health conditions, including:

Major Depressive Disorder (MDD)
Obsessive-Compulsive Disorder (OCD)
Panic Disorder
Post-Traumatic Stress Disorder (PTSD)
Social Anxiety Disorder
Premenstrual Dysphoric Disorder (PMDD)
Sertraline works by increasing the levels of serotonin, a natural substance in the brain that helps maintain mental balance.

Before Using Sertraline
Allergies
Inform your doctor if you have any allergies to sertraline or any other medications, foods, dyes, or preservatives.

Pediatric and Geriatric Use
Pediatric: Approved for OCD in children age 6 and older. Use for depression or other conditions in pediatric patients is not typically recommended.
Geriatric: Older adults may be more sensitive to side effects such as dizziness and an increased risk of bleeding when combined with NSAIDs.
Pregnancy and Breastfeeding
Pregnancy: Sertraline may pose some risk during pregnancy, especially in the third trimester. Discuss potential benefits and risks with your doctor.
Breastfeeding: Sertraline passes into breast milk in small amounts. Consult your doctor regarding whether to continue breastfeeding while on this medication.
Interactions
Medications
Sertraline may interact with:

MAO inhibitors (e.g., phenelzine, selegiline): Do not use sertraline within 14 days of stopping an MAOI.
Other antidepressants (e.g., SSRIs, SNRIs, tricyclics): May increase risk of serotonin syndrome.
NSAIDs or blood thinners (e.g., aspirin, warfarin): May increase risk of bleeding.
Triptans for migraines (e.g., sumatriptan): May increase the risk of serotonin syndrome.
Food, Alcohol, and Tobacco
Food: Sertraline can be taken with or without food.
Alcohol: Avoid alcohol, as it may intensify drowsiness or dizziness.
Proper Use of Sertraline Tablets
Dosing Instructions
Typically taken once daily (morning or evening), as prescribed by your doctor.
May start at a low dose (e.g., 25–50 mg/day) and gradually increase based on clinical response.
Swallow tablets whole with water.
Missed Dose
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double doses to catch up.

Storage
Store at room temperature, away from moisture, heat, and direct light. Keep out of reach of children.

Precautions While Using Sertraline
Mood and Behavior Monitoring: Watch for worsening depression, suicidal thoughts, or unusual behavior changes, particularly during initial treatment or dose adjustments.
Serotonin Syndrome: Seek immediate medical attention if you experience symptoms such as high fever, agitation, confusion, or muscle rigidity.
Bleeding Risk: Inform your doctor if you notice unusual bruising or bleeding, especially if you are also taking NSAIDs, aspirin, or blood thinners.
Driving or Operating Machinery: Sertraline can cause dizziness or drowsiness. Avoid activities requiring alertness until you know how it affects you.
Side Effects of Sertraline Tablets
Serious Side Effects (Seek Immediate Medical Attention)
Signs of allergic reaction (e.g., rash, itching, swelling, difficulty breathing)
Unusual changes in mood or behavior, thoughts of self-harm
Seizures
Irregular heartbeat, fainting
Common Side Effects
Nausea, diarrhea
Dry mouth
Drowsiness or dizziness
Sweating
Sexual dysfunction (decreased libido, difficulty achieving orgasm)
Headache or insomnia
Emergency Situations and Overdose
Symptoms of overdose may include severe dizziness, fainting, irregular heartbeat, or seizures. If an overdose is suspected, seek emergency medical attention immediately.

Contact your healthcare provider if you have any concerns or experience persistent side effects while taking sertraline. Always follow your doctor’s instructions for safe and effective use.

Full Prescribing Information.

MedlinePlus Drug Information.

National Alliance on Mental Illness.